|female Cannabis sativa, recreational/medicinal marijuana|
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Cannabis sativa is an annual herbaceous flowering plant indigenous to eastern Asia but now of cosmopolitan distribution due to widespread cultivation. It has been cultivated throughout recorded history, used as a source of industrial fiber, seed oil, food, recreation, religious and spiritual moods and medicine. Each part of the plant is harvested differently, depending on the purpose of its use. The species was first classified by Carl Linnaeus in 1753. The word "sativa" means things that are cultivated.
The flowers of Cannabis sativa are unisexual and plants are most often either male or female. It is a short-day flowering plant, with staminate (male) plants usually taller and less robust than pistillate (female or male) plants. The flowers of the female plant are arranged in racemes and can produce hundreds of seeds. Male plants shed their pollen and die several weeks prior to seed ripening on the female plants. Under typical conditions with a light period of 12 to 14 hours both sexes are produced in equal numbers because of heritable X and Y chromosomes. Although genetic factors dispose a plant to become male or female, environmental factors including the diurnal light cycle can alter sexual expression. Naturally occurring monoecious plants, with both male and female parts, are either sterile or fertile but artificially induced "hermaphrodites" can have fully functional reproductive organs. "Feminized" seed sold by many commercial seed suppliers are derived from artificially "hermaphroditic" females that lack the male gene, or by treating the plants with hormones or silver thiosulfate.
Although the main psychoactive constituent of Cannabis is tetrahydrocannabinol (THC), the plant is known to contain more than 500 compounds, among them at least 113 cannabinoids; however, most of these "minor" cannabinoids are only produced in trace amounts. Besides THC, another cannabinoid produced in high concentrations by some plants is cannabidiol (CBD), which is not psychoactive but has recently been shown to block the effect of THC in the nervous system. Differences in the chemical composition of Cannabis varieties may produce different effects in humans. Synthetic THC, called dronabinol, does not contain cannabidiol (CBD), cannabinol (CBN), or other cannabinoids, which is one reason why its pharmacological effects may differ significantly from those of natural Cannabis preparations.
- α-Humulene, contributes to the characteristic aroma of Cannabis sativa
- Caryophyllene, with which some hashish detection dogs are trained
Difference between C. sativa and C. indica
Human intervention has produced variation within the species and some authorities only recognize one species in the genus that has had divergent selective pressure to either produce plants with more fiber or plants with greater THC content. Large variability exists within either species, and there is an expanding discussion whether the existing paradigm used to differentiate species adequately represents the variability found within the genus Cannabis. There are five chemotaxonomic types of Cannabis: one with high levels of THC, one which is more fibrous and has higher levels of CBD, one that is an intermediate between the two, another one with high levels of cannabigerol (CBG), and the last one almost without cannabinoids.
Cannabis strains with relatively high CBD:THC ratios are less likely to induce anxiety than vice versa. This may be due to CBD's antagonistic effects at the cannabinoid receptors, compared to THC's partial agonist effect. CBD is also a 5-HT1A receptor (serotonin) agonist, which may also contribute to an anxiolytic-content effect. The effects of sativa are well known for its cerebral high, while indica is well known for its sedative effects which some prefer for night time use. Both types are used as medical cannabis. Indica plants are normally shorter and stockier than sativas. Indicas have broader, deeply serrated leaves and a compact and dense flower cluster.
Cannabis sativa seeds are chiefly used to make hempseed oil which can be used for cooking, lamps, lacquers, or paints. They can also be used as caged-bird feed, as they provide a source of nutrients for most animals. The flowers and fruits (and to a lesser extent the leaves, stems, and seeds) contain psychoactive chemical compounds known as cannabinoids that are consumed for recreational, medicinal, and spiritual purposes. When so used, preparations of flowers and fruits (called marijuana) and leaves and preparations derived from resinous extract (e.g., hashish) are consumed by smoking, vaporising, and oral ingestion. Historically, tinctures, teas, and ointments have also been common preparations. In traditional medicine of India in particular C. sativa has been used as hallucinogenic, hypnotic, sedative, analgesic, and anti-inflammatory agent.
A Cannabis plant in the vegetative growth phase of its life requires more than 12–13 hours of light per day to stay vegetative. Flowering usually occurs when darkness equals at least 12 hours per day[dubious ]. The flowering cycle can last anywhere between nine and fifteen weeks, depending on the strain and environmental conditions. When the production of psychoactive cannabinoids is sought, female plants are grown separately from male plants to induce parthenocarpy in the female plant's fruits (popularly called "'sin semilla' which is Spanish for 'without seed'" ) and increase the production of cannabinoid-rich resin.
In soil, the optimum pH for the plant is 6.3 to 6.8. In hydroponic growing, the nutrient solution is best at 5.2 to 5.8, making Cannabis well-suited to hydroponics because this pH range is hostile to most bacteria and fungi.
Tissue culture multiplication has become important in producing medically important clones, while seed production remains the generally preferred means of multiplication. Sativa plants have narrow leaves and grow best in warm environments. They do, however, take longer to flower than their Indica counterparts, and they grow taller than the Indica cannabis strains as well. 
Broadly, there are three main cultivar groups of cannabis that are cultivated today:
- Cultivars primarily cultivated for their fibre, characterised by long stems and little branching.
- Cultivars grown for seed which can be eaten entirely raw or from which hemp oil is extracted.
- Cultivars grown for medicinal or recreational purposes. A nominal if not legal distinction is often made between industrial hemp, with concentrations of psychoactive compounds far too low to be useful for that purpose, and marijuana.
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