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Epigenetic regulation by long noncoding RNAs
JT Lee - Science, 2012 - science.org
Recent studies show that transcription of the mammalian genome is not only pervasive but
also enormously complex. It is estimated that an average of 10 transcription units, the vast …
also enormously complex. It is estimated that an average of 10 transcription units, the vast …
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and …
DR Nelson, DC Zeldin, SMG Hoffman… - Pharmacogenetics …, 2004 - journals.lww.com
Objectives Completion of both the mouse and human genome sequences in the private and
public sectors has prompted comparison between the two species at multiple levels. This …
public sectors has prompted comparison between the two species at multiple levels. This …
[PDF][PDF] Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
G Meister, M Landthaler, A Patkaniowska, Y Dorsett… - Molecular cell, 2004 - cell.com
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational
repression, or a combination of both. The human Argonaute family has eight members, four …
repression, or a combination of both. The human Argonaute family has eight members, four …
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
T Watanabe, Y Totoki, A Toyoda, M Kaneda… - Nature, 2008 - nature.com
RNA interference (RNAi) is a mechanism by which double-stranded RNAs (dsRNAs)
suppress specific transcripts in a sequence-dependent manner. dsRNAs are processed by …
suppress specific transcripts in a sequence-dependent manner. dsRNAs are processed by …
[HTML][HTML] Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
RNA regulation: a new genetics?
JS Mattick - Nature Reviews Genetics, 2004 - nature.com
Do non-coding RNAs that are derived from the introns and exons of protein-coding and non-
protein-coding genes represent a fundamental advance in the genetic operating system of …
protein-coding genes represent a fundamental advance in the genetic operating system of …
[BOOK][B] Genetics and philosophy: An introduction
P Griffiths, K Stotz - 2013 - books.google.com
In the past century, nearly all of the biological sciences have been directly affected by
discoveries and developments in genetics, a fast-evolving subject with important theoretical …
discoveries and developments in genetics, a fast-evolving subject with important theoretical …
Empirical Analysis of Transcriptional Activity in the Arabidopsis Genome
K Yamada, J Lim, JM Dale, H Chen, P Shinn, CJ Palm… - science, 2003 - science.org
Functional analysis of a genome requires accurate gene structure information and a
complete gene inventory. A dual experimental strategy was used to verify and correct the …
complete gene inventory. A dual experimental strategy was used to verify and correct the …
Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function
The mammalian transcriptome contains many non-protein-coding RNAs (ncRNAs), but most
of these are of unclear significance and lack strong sequence conservation, prompting …
of these are of unclear significance and lack strong sequence conservation, prompting …
[HTML][HTML] Regulating gene expression through RNA nuclear retention
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …