Authors
Sun-Ho Lee, Williams Turpin, Osvaldo Espin-Garcia, Juan Antonio Raygoza Garay, Michelle I Smith, Haim Leibovitzh, Ashleigh Goethel, Dan Turner, David Mack, Colette Deslandres, Maria Cino, Guy Aumais, Remo Panaccione, Kevan Jacobson, Alain Bitton, A Hillary Steinhart, Hien Q Huynh, Fred Princen, Paul Moayyedi, Anne M Griffiths, Mark S Silverberg, Andrew D Paterson, Wei Xu, Kenneth Croitoru
Publication date
2021/11/1
Journal
Gastroenterology
Volume
161
Issue
5
Pages
1540-1551
Publisher
WB Saunders
Description
Background and Aims
Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn’s disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDRs) of CD patients is an independent risk factor for future CD development.
Methods
We measured host serum antibody response to 6 microbial antigens at enrollment (Prometheus enzyme-linked immunosorbent assay test: anti-Saccharomyces cerevisiae antibodies immunoglobulin A/immunoglobulin G, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS). We used samples at enrollment of prospectively followed healthy FDRs from a nested case-control cohort of the Crohn’s and Colitis Canada Genetics Environment Microbial Project. Those who later developed CD (n = 77) were matched 1:4 by age, sex, follow-up …
Total citations
Scholar articles
SH Lee, W Turpin, O Espin-Garcia, JAR Garay… - Gastroenterology, 2021