Authors
Armando Stabile, Antony Pellegrino, Elio Mazzone, Donato Cannoletta, Mario de Angelis, Francesco Barletta, Simone Scuderi, Vito Cucchiara, Giorgio Gandaglia, Daniele Raggi, Andrea Necchi, Pierre Karakiewicz, Francesco Montorsi, Alberto Briganti
Publication date
2022/2/1
Source
European Urology Oncology
Volume
5
Issue
1
Pages
1-17
Publisher
Elsevier
Description
Context
The role of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA) in the primary staging for patients with prostate cancer (PCa) is still debated.
Objective
To analyze published studies reporting the accuracy of PSMA PET/CT for detecting lymph node invasion (LNI) at pelvic lymph node dissection (PLND).
Evidence acquisition
A search of PubMed/MEDLINE, Cochrane library’s Central, EMBASE and Scopus databases, from inception to May 2021, was conducted. The primary outcome was to evaluate the sensitivity, specificity, positive (PPV) and negative (NPV) predictive values of PSMA PET/CT in detecting LNI on a per-patient level. As a secondary outcome, NPV of PET PSMA was tested on a per-node–level analysis. Detection rates were pooled using random-effect models. Preplanned subgroup analyses tested the diagnostic accuracy after …
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Scholar articles
A Stabile, A Pellegrino, E Mazzone, D Cannoletta… - European Urology Oncology, 2022