Authors
Elio Mazzone, Armando Stabile, Francesco Pellegrino, Giuseppe Basile, Daniele Cignoli, Giuseppe Ottone Cirulli, Gabriele Sorce, Francesco Barletta, Simone Scuderi, Carlo Andrea Bravi, Vito Cucchiara, Nicola Fossati, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti
Publication date
2021/10/1
Source
European urology oncology
Volume
4
Issue
5
Pages
697-713
Publisher
Elsevier
Description
Context
The variability of the positive predictive value (PPV) represents a significant factor affecting the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI).
Objective
To analyze published studies reporting mpMRI PPV and the reasons behind the variability of clinically significant prostate cancer (csPCa) detection rates on targeted biopsies (TBx) according to Prostate Imaging Reporting and Data System (PI-RADS) version 2 categories.
Evidence acquisition
A search of PubMed, Cochrane library’s Central, EMBASE, MEDLINE, and Scopus databases, from January 2015 to June 2020, was conducted. The primary and secondary outcomes were to evaluate the PPV of PI-RADS version 2 in detecting csPCa and any prostate cancer (PCa), respectively. Individual authors’ definitions for csPCa and PI-RADS thresholds for positive mpMRI were accepted. Detection rates, used as a surrogate of …
Total citations
Scholar articles
E Mazzone, A Stabile, F Pellegrino, G Basile, D Cignoli… - European urology oncology, 2021