Cannabis Sativa

Authors
Peggy Raynaud, Joshua Tate, Céline Callens, Sabine Cordi, Patrick Vandersmissen, Rodolphe Carpentier, Christine Sempoux, Olivier Devuyst, Christophe E Pierreux, Pierre Courtoy, Karin Dahan, Katty Delbecque, Sébastien Lepreux, Marco Pontoglio, Lisa M Guay‐Woodford, Frédéric P Lemaigre
Publication date
2011/6
Journal
Hepatology
Volume
53
Issue
6
Pages
1959-1966
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Ductal plate malformations (DPMs) are developmental anomalies considered to result from lack of ductal plate remodeling during bile duct morphogenesis. In mice, bile duct development is initiated by the formation of primitive ductal structures lined by two cell types, namely ductal plate cells and hepatoblasts. During ductal plate remodeling, the primitive ductal structures mature to ducts as a result from differentiation of the ductal plate cells and hepatoblasts to cholangiocytes. Here, we report this process is conserved in human fetal liver. These findings prompted us to evaluate how DPMs develop in three mouse models, namely mice with livers deficient in hepatocyte nuclear factor 6 (HNF6), HNF1β, or cystin‐1 (cpk [congenital polycystic kidney] mice). Human liver from a patient with a HNF1B/TCF2 mutation, and from fetuses affected with autosomal recessive polycystic kidney disease (ARPKD) were also analyzed …
Total citations
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