Sir John Spring may refer to:

• John Spring (MP for Northampton), in 1399 MP for Northampton
• Sir John Spring of Lavenham (died 1547), English merchant and politician
• Sir John Spring, 5th Baronet (1674–1740), English baronet
• Sir John Spring, 6th Baronet (died 1769), English baronet
• John Spring (cricketer) (1833–1907), New Zealand cricketer
• John Hopkins Spring (1862–1933), San Francisco real estate developer, see John Hopkins Spring Estate