Pietsch is a German surname. It may refer to:

• Bill Pietsch (1935–2004), American politician and businessman
• Charles Francis Pietsch (1844–1920), American German-language newspaper publisher
• Coral Wong Pietsch (born 1947), American brigadier general
• Gustav Pietsch (1893–1975), German captain, resistance fighter, and politician
• Hans Pietsch (Go player) (1968–2003), German Go player
• Hans Pietsch (1907–1967) German mathematician and cryptographer
• Janine Pietsch (born 1982), German Olympian backstroke swimmer
• Ludwig Pietsch (1824–1911), German painter, art critic, and writer
• Paul Pietsch (1911–2012), German racing driver and magazine publisher
• Sara Mohr-Pietsch (born 1980), British music broadcaster
• Theodore Wells Pietsch I (1869–1930), American architect
• Theodore Wells Pietsch II (1912–1993), American automobile stylist and industrial designer
• Theodore Wells Pietsch III (born 1945), American evolutionary biologist
• Vonnie Pietsch (born 1936), American politician