Pierotti is a family name. It may refer to:

• Al Pierotti, American football and baseball player
• Giuseppe Pierotti, Italian sculptor and painter
• John Pierotti, American editorial cartoonist
• Juan Mencarini Pierotti, Spanish mid-rank employee of the Chinese Maritime Customs Service
• Piero Pierotti, Italian director, screenwriter and journalist
• Raffaele Pierotti (1836–1905), Italian cardinal and theologian
• Raquel Pierotti, Uruguayan mezzo-soprano opera singer
• Santiago Pierotti, Argentine professional footballer