This is a list of notable people from Multan city and Multan District.

• Syed Ata Ullah Shah Bukhari, Muslim scholar
• Anwaar Ahmad, writer and academician

• Aamer Bashir, cricketer
• Ali Sawal, cricketer and sports commentator
• Arif Mehmood, football player
• Asmavia Iqbal, cricketer
• Aamer Yamin, cricketer
• Farhan Khan, Omani cricketer
• Inzamam-ul-Haq, cricketer
• Naveed Akram, football player
• Rahat Ali, cricketer
• Sania Khan, cricketer
• Saqib Ali, cricketer
• Sohaib Maqsood, cricketer
• Sukhan Faiz, cricketer
• Khurram Khan, UAE cricketer
• Robin Kreyer (1910-1987), cricketer and British Army/British Indian Army officer
• Imam-ul-Haq, cricketer

• Ahmad Shah Durrani, founder of Durrani Empire
• Bahlul Lodi, founder of Lodhi dynasty
• Fateh Daud, ruler of Multan
• Khizr Khan, founder of Sayyid dynasty of Delhi sultanate
• Nawab Ali Mohammad Khan Khakwani, Governor of Multan, Durrani Empire
• Nawab Zahid Khan (From 1738 to 1748)
• Nawab Shuja Khan - Governor of Multan and founder of Shujabad
• Nawab Muzaffar Khan Governor of Multan and founder of Muzaffargarh

• Buland Akhtar Rana, politician and civil servant.
• Sahibzada Farooq Ali, former Speaker of the National Assembly
• Fakhar Imam, former Speaker of the National Assembly
• Malik Ahmed Hussain Dehar,Former Member of National Assembly
• Hamid Raza Gillani, politician
• Zain ul Abadeen Gillani, politician
• Hamid Saeed Kazmi, politician
• Hina Rabbani Khar, politician
• Javed Hashmi, politician
• Najaf Abbasi (politician)
• Rafique Rajwana, Senator & Governor Punjab
• Shaukat Tarin, banker, politician
• Sikandar Hayat Khan, Punjabi politician
• Sheikh Muhammad Tahir Rasheed, politician
• Yousaf Raza Gillani, former Prime Minister of Pakistan
• Shah Mehmood Qureshi, former Foreign Minister of Pakistan
• Umar Bashir, politician Pakistan Tareek-e-Insaf

• Dewan Mulraj, Sikh saint
• Fariduddin Ganjshakar, Saint
• Mai Maharban, female saint
• Syed Musa Pak, Muslim Sufi
• Rukn-e-Alam, Muslim Sufi

• H. Gobind Khorana, Nobel prize winner scientist

• Mazhar Kaleem, writer and novelist
• Muhammad Sharif, cosmologist
• Mahindar Pall Singh, Sikh MPA, politician and Business man
• Ravi Batra, Indian-American economist and professor
• Syed Noor Ul Hassan Bukhari (Scholar writer )
• Sadiq Ali Shahzad, sculptor
• Saima Noor, film actress
• Najam Sheraz, singer
• Hamza Ali Abbasi, film actor
• Hajra Yamin, actress