Jay Leno (born 1950) is an American comedian and talk show host.

Leno may also refer to:

• Leno (surname)
• Leno, Lombardy, Italy, a town and comune
• Leno (stream), a stream in Italy
• Leno weave, a pattern in weaving
• Leño, a Spanish hard rock band from 1978 to 1983
  • Leño (album) (1979)
• Leno, a stock character in theatre of ancient Rome who is a slave dealer or pimp

• The Tonight Show with Jay Leno (1992–2009, 2010–2014)
• The Jay Leno Show (2009–2010)
• 13212 Jayleno (1989 GN6, 1993 GQ, 1997 JL13), a main-belt asteroid
• All pages with titles beginning with leno
• All pages with titles containing leno
• Lenno, a former comune in the province of Como, Italy, now part of Tremezzina