Le Tonnelier de Breteuil was a French surname, held by:
- Louis Nicolas Le Tonnelier de Breteuil (1648–1728), officer of the household of Louis XIV
- François Victor Le Tonnelier de Breteuil (1686–1743), twice secretary of state for war
- Gabrielle Émilie Le Tonnelier de Breteuil (1706–1749), mathematician, daughter of Louis Nicolas
- Louis Auguste Le Tonnelier de Breteuil (1730–1807), diplomat and politician