Jorge Castro may refer to:
- Jorge Castro (boxer) (born 1967), Argentine boxer
- Jorge Castro (footballer) (born 1990), Costa Rican footballer
- Jorge Castro (athlete), see 2007 NACAC Championships – Results
- Jorge Castro (gymnast), Mexican Olympic gymnast
- Jorge Daniel Castro (born 1950), Colombian police office and business administrator
- Jorge Lara Castro (born 1945), Paraguayan lawyer, sociologist, and diplomat
- Jorge Castro Muñoz (born 1956), Chilean politician and former major of Valparaíso, Chile