James O'Toole may refer to:

• James O'Toole (business figure), pioneer of the internet and internet marketing in Australia,
• James O'Toole (American politician) (born 1958), politician in the Missouri House of Representatives
• James O'Toole (reporter), American journalist
• James O'Toole (mobster) (1929–1973), Irish-American criminal
• James O'Toole (Irish politician) (died 1969), Irish Fianna Fáil politician

See also[edit]

• Jim O'Toole (1937–2015), American baseball player