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James C. Carrington
Born1960 (age 63–64)
Redondo Beach, CA
EducationUniversity of California-Riverside, University of California-Berkeley
Known forRNA Silencing
SpouseTeri[1]
ChildrenFour[1]
Scientific career
InstitutionsTexas A&M University, Washington State University, Oregon State University, Donald Danforth Plant Science Center
Doctoral advisorT. Jack Morris
Websitewww.danforthcenter.org/our-work/principal-investigators/james-carrington/

James C. Carrington is a plant biologist and the current president of the Donald Danforth Plant Science Center. In 2005 he was elected a fellow of the American Association for the Advancement of Science and in 2008 he was elected to the National Academy of Sciences.[2]

Early life and education[edit]

Carrington was born in Redondo Beach, California in 1960. He attended the University of California, Riverside where he studied biology and worked as an undergraduate research assistant for William Dawson, a plant virologist. After graduating, he pursued graduate training at the University of California, Berkeley working in the lab of T. Jack Morris[2] where he worked on sequencing and analyzing the genomes of plant viruses[3] and graduated in 1986. After completing his PhD, Carrington was a postdoc at North Carolina State University in the research group of William Dougherty until 1988.[2]

Career[edit]

In 1988 Carrington was hired as an assistant professor in the department of biology at Texas A&M University. At Texas A&M he was promoted to Associate and later full professor. After nine years working at Texas A&M, Carrington was hired at Washington State University. In 2001 he moved to Oregon State University where he directed the Center for Genome Research and Biocomputing.[2] In May 2011, Carrington began as the new president of the Donald Danforth Plant Science Center.[1]

Research[edit]

Carrington's early work on plant virology lead to the discovery that some plant viruses produce proteins which suppress post transcriptional gene silencing in plants and that this suppression is necessary in order for these viruses to spread, demonstrating that RNA silencing in plants functions as an antivirus defense mechanism.[2] Carrington moved on to study natural small RNA molecules produced by plants including microRNAs and siRNAs,[4][5] identifying roles for these gene silencing mechanisms in both plant development and chromatin state maintenance.[6][7]

Recognition[edit]

References[edit]

  1. ^ a b c "Plant Science Center names James Carrington as new president". 6 November 2010.
  2. ^ a b c d e f Trivedi, Bijal P. (2010). "Profile of James C. Carrington". Proceedings of the National Academy of Sciences. 107 (28): 12411–12412. Bibcode:2010PNAS..10712411T. doi:10.1073/pnas.1008044107. PMC 2906593. PMID 20616018.
  3. ^ Carrington, James C.; Heaton, Louis A.; Zuidema, Douwe; Hillman, Bradley I.; Morris, T.J. (1989). "The genome structure of turnip crinkle virus". Virology. 170 (1): 219–226. doi:10.1016/0042-6822(89)90369-3. PMID 2718381.
  4. ^ Allen, Edwards; Xie, Zhixin; Gustafson, Adam M.; Carrington, James C. (2005). "MicroRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants". Cell. 121 (2): 207–221. doi:10.1016/j.cell.2005.04.004. PMID 15851028. S2CID 18056486.
  5. ^ Fahlgren, Noah; Howell, Miya D.; Kasschau, Kristin D.; Chapman, Elisabeth J.; Sullivan, Christopher M.; Cumbie, Jason S.; Givan, Scott A.; Law, Theresa F.; Grant, Sarah R.; Dangl, Jeffery L.; Carrington, James C. (2007). "High-Throughput Sequencing of Arabidopsis microRNAs: Evidence for Frequent Birth and Death of MIRNA Genes". PLOS ONE. 2 (2): e219. Bibcode:2007PLoSO...2..219F. doi:10.1371/journal.pone.0000219. PMC 1790633. PMID 17299599.
  6. ^ Palatnik, Javier F.; Allen, Edwards; Wu, Xuelin; Schommer, Carla; Schwab, Rebecca; Carrington, James C.; Weigel, Detlef (2003). "Control of leaf morphogenesis by microRNAs". Nature. 425 (6955): 257–263. Bibcode:2003Natur.425..257P. doi:10.1038/nature01958. PMID 12931144. S2CID 992057.
  7. ^ Xie, Zhixin; Johansen, Lisa K.; Gustafson, Adam M.; Kasschau, Kristin D.; Lellis, Andrew D.; Zilberman, Daniel; Jacobsen, Steven E.; Carrington, James C. (2004). "Genetic and Functional Diversification of Small RNA Pathways in Plants". PLOS Biology. 2 (5): e104. doi:10.1371/journal.pbio.0020104. PMC 350667. PMID 15024409.
  8. ^ "Ruth Allen Award".
  9. ^ Lempinen, E. W. (2004). AAAS members elected as fellows. Science, 306(5697), 825-828
  10. ^ "Fellow of ASPB".

External links[edit]

source: https://en.wikipedia.org/wiki/James_C._Carrington

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