Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene .
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Function [ edit ] This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
References [ edit ] Further reading [ edit ]
Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2" . Nucleic Acids Res . 31 (12): 3016–26. doi :10.1093/nar/gkg431 . PMC 162335 PMID 12799427 . Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells" . Cancer Res . 69 (4): 1375–82. doi :10.1158/0008-5472.CAN-08-2896 . PMC 4264605 PMID 19190336 . Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression" . FASEB J . 24 (12): 4825–34. doi :10.1096/fj.10-167049 PMID 20702774 . S2CID 35708173 . Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression" . FASEB J . 24 (12): 4825–34. doi :10.1096/fj.10-167049 PMID 20702774 . S2CID 35708173 . Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity" . Mol. Cell. Biol . 31 (14): 2889–901. doi :10.1128/MCB.00974-10 . PMC 3133407 PMID 21576369 . Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2" . PLOS ONE . 6 (8): e24100. Bibcode :2011PLoSO...624100T . doi :10.1371/journal.pone.0024100 PMC 3162591 PMID 21887377 . Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma" . PLOS ONE . 7 (11): e49705. Bibcode :2012PLoSO...749705N . doi :10.1371/journal.pone.0049705 PMC 3504151 PMID 23185413 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
