Flora MacDonald was an 18th-century member of Clan Macdonald of Sleat.
Flora MacDonald may also refer to:
- Flora MacDonald (politician), Canadian politician and humanitarian
- Flora MacDonald Denison, Canadian activist, journalist and businesswoman
- F. M. Mayor (Flora Macdonald Mayor), English novelist and short story writer
- Flora Macdonald Reid, British, Scottish painter
- Flora MacDonald College, women's college in Red Springs, North Carolina, United States of America