THC Science

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Summary

Description	English: SREBF-1 is synthesized as inactive precursors in ER, where it resides in a complex with SCAP, a sterol sensor, and INSIG-1. Upon activation, when sterol levels are low, SCAP undergoes a conformational change and is released from INSIG. SCAP assists the transport of the precursor SREBF-1 to the Golgi apparatus followed by a two-step proteolytic cleavage thus releasing a transcriptionally active N-terminal domain. This domain is subsequently translocated to the nucleus, resulting in the expression of SREBF target genes.
Date	30 March 2014, 22:00:12
Source	Own work
Author	VeraOli

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	20:01, 30 March 2014		945 × 597 (239 KB)	VeraOli	User created page with UploadWizard

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