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Summary
| Description |
The structure of the human presenilin-1 protein (orange) interacting with a fragment of one of its protein substrates, Notch (green). The catalytic aspartate sites are highlighted in blue spheres. Rendered using PyMOL from chains B and E of PDB: 6IDF, a cryo-electron microscopy structure of the assembled gamma-secretase protein complex. In the construct used for the structure, D385 (aspartate on the left) was mutated to alanine; this residue has been modeled as an aspartate in this image for illustrative purposes. Structural basis of Notch recognition by human gamma-secretase Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., Lei, J., Shi, Y. (2019) Nature 565: 192-197. PubMed: 30598546 DOI: 10.1038/s41586-018-0813-8 |
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| Author | Opabinia regalis |
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Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 05:43, 28 January 2021 | | 800 × 800 (368 KB) | Opabinia regalis | {{Information |Description=The structure of the human presenilin-1 protein (orange) interacting with a fragment of one of its protein substrates, Notch (green). The catalytic aspartate sites are highlighted in blue spheres. Rendered using PyMOL from chains B and E of {{PDB|6IDF}}, a cryo-electron microscopy structure of the assembled gamma-secretase protein complex. Structural basis of Notch recognition by human gamma-secretase Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., Lei, J.,... |
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