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EXTL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OMX, 1OMZ, 1ON6, 1ON8
Identifiers
Aliases	EXTL2, EXTR2, exostosin-like glycosyltransferase 2, exostosin like glycosyltransferase 2
External IDs	OMIM: 602411 MGI: 1889574 HomoloGene: 1102 GeneCards: EXTL2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,895,179 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,822,666 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	2135
	58193
	ENSG00000162694
	ENSMUSG00000027963
	Q9UBQ6
	Q9ES89
	NM_001033025; NM_001261440; NM_001261441; NM_001261442; NM_001439
	NM_001163514; NM_001163515; NM_021388
	NP_001028197; NP_001248369; NP_001248370; NP_001248371; NP_001430
	NP_001156986; NP_001156987; NP_067363
	Wikidata
View/Edit Human	View/Edit Mouse

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene.^[5]^[6]^[7] EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027963 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
^ Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.
^ "Entrez Gene: EXTL2 exostoses (multiple)-like 2".

External links[edit]

PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027963 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9450183-5] Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.

[pmid15831490-6] Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.

[entrez-7] "Entrez Gene: EXTL2 exostoses (multiple)-like 2".

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