Protein-coding gene in the species Homo sapiens
Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene .[5] [6]
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[6]
Interactions [ edit ]
DGKZ has been shown to interact with P110α .[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000149091 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040479 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta" . J Biol Chem . 271 (17): 10230–6. doi :10.1074/jbc.271.17.10230 . PMID 8626588 .
^ a b "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa" .
^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta" . J. Biol. Chem . 278 (41): 39542–7. doi :10.1074/jbc.M307153200 . ISSN 0021-9258 . PMID 12890670 .
Further reading [ edit ]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Ding L, Bunting M, Topham MK, et al. (1997). "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5519–24. Bibcode :1997PNAS...94.5519D . doi :10.1073/pnas.94.11.5519 . PMC 20810 . PMID 9159104 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Topham MK, Bunting M, Zimmerman GA, et al. (1998). "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta". Nature . 394 (6694): 697–700. Bibcode :1998Natur.394..697T . doi :10.1038/29337 . PMID 9716136 . S2CID 204999472 .
Liu Z, Chang GQ, Leibowitz SF (2001). "Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation" . J. Biol. Chem . 276 (8): 5900–7. doi :10.1074/jbc.M007311200 . PMID 11078732 .
Topham MK, Prescott SM (2001). "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism" . J. Cell Biol . 152 (6): 1135–43. doi :10.1083/jcb.152.6.1135 . PMC 2199204 . PMID 11257115 .
Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions" . J. Biol. Chem . 276 (28): 26526–33. doi :10.1074/jbc.M104156200 . PMID 11352924 .
Santos T, Carrasco S, Jones DR, et al. (2002). "Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity" . J. Biol. Chem . 277 (33): 30300–9. doi :10.1074/jbc.M200999200 . PMID 12015310 .
Zhong XP, Hainey EA, Olenchock BA, et al. (2002). "Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta" . J. Biol. Chem . 277 (34): 31089–98. doi :10.1074/jbc.M203818200 . PMID 12070163 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Zhong XP, Hainey EA, Olenchock BA, et al. (2003). "Enhanced T cell responses due to diacylglycerol kinase zeta deficiency". Nat. Immunol . 4 (9): 882–90. doi :10.1038/ni958 . PMID 12883552 . S2CID 27265140 .
Luo B, Prescott SM, Topham MK (2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta" . J. Biol. Chem . 278 (41): 39542–7. doi :10.1074/jbc.M307153200 . PMID 12890670 .
Abramovici H, Hogan AB, Obagi C, et al. (2004). "Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins" . Mol. Biol. Cell . 14 (11): 4499–511. doi :10.1091/mbc.E03-03-0190 . PMC 266768 . PMID 14551255 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Davidson L, Pawson AJ, López de Maturana R, et al. (2004). "Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src" . J. Biol. Chem . 279 (12): 11906–16. doi :10.1074/jbc.M310784200 . PMID 14707140 .
Luo B, Prescott SM, Topham MK (2005). "Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism". Cell. Signal . 16 (8): 891–7. doi :10.1016/j.cellsig.2004.01.010 . PMID 15157668 .
Avila-Flores A, Santos T, Rincón E, Mérida I (2005). "Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid" . J. Biol. Chem . 280 (11): 10091–9. doi :10.1074/jbc.M412296200 . PMID 15632115 .
Los AP, Vinke FP, de Widt J, et al. (2006). "The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta" . J. Biol. Chem . 281 (2): 858–66. doi :10.1074/jbc.M502693200 . PMID 16286473 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .