Charles Drew may refer to:

• Charles R. Drew (1904–1950), American physician, surgeon, and medical researcher
• Charles Drew (cricketer) (1888–1960), Australian cricketer
• Charles Drew (surgeon) (1916–1987), cardiothoracic surgeon
• Charles S. Drew (1825–1886), representative in the legislature of the Oregon Territory of the United States
• USNS Charles Drew (T-AKE-10), a 2010 Lewis and Clark-class dry cargo ship of the United States Navy
• Charles John Drew (c. 1690–1740), English lawyer murdered in Suffolk by his namesake son