Sayegh is an Arabic surname which means goldsmith. It has also some variants, like Saieg or Sayigh. Notable people with the surname include:

• Abdul Nasser Al-Sayegh (born 1959), Kuwaiti fencer
• Adnan Al-Sayegh (born 1955), Iraqi singer
• Ahmad Ali Al Sayegh (born 1962), Emirati businessman and CEO of Dolphin Energy
• Bashar Al-Sayegh (born 1977), Kuwaiti journalist and politician
• Daud as-Sayegh, Iraqi communist politician
• Fayez Sayegh, Palestinian-American academic
• Fayez Sayegh (1922–1980), Palestinian-American academic and civil servant
• Faisal Al Sayegh, Lebanese Druze politician
• Hani al-Sayegh, Saudi citizen, and alleged member of Hezbollah Al-Hejaz
• Jean Sayegh (born 1981), Canadian water polo player
• Jim Sayegh, American television director
• Joe Sayegh, (1884–1946) Syrian born New Zealand politician and businessman
• Maximos IV Sayegh (1878–1967), Syrian cardinal
• May Sayegh (1940–2023), Palestinian poet, feminist, political activist and writer
• Nader Sayegh, Jordanian-American politician, attorney, and educator
• Patricio Sayegh (born 1967), Argentine professional association footballer
• Percy Sayegh (born 1965), Lebanese swimmer
• Salim Sayegh, Lebanese academic and politician
• Salim Sayegh (Catholic bishop) (born 1935), Patriarchal Vicar for Jordan in the Latin Patriarch of Jerusalem
• Tony Sayegh, United States Assistant Secretary of the Treasury for Public Affairs

• Anis Sayigh (1931–2009), Palestinian historian
• Fayez Sayigh (1922–1980), Palestinian academic
• Rosemary Sayigh (born 1935), British-Palestinian writer and journalist
• Tawfiq Sayigh (1923–1971) Palestinian academic, writer and journalist.
• Yezid Sayigh (born 1955), Palestinian historian
• Yusif Sayigh (1916–2004), Palestinian economist