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Pharmacokinetics and pharmacodynamics in clinical use of scopolamine
UD Renner, R Oertel, W Kirch - Therapeutic drug monitoring, 2005 - journals.lww.com
… Similar to atropine, L-(−)-scopolamine is a nonselective muscarinic antagonist. The sensitivity
of … Scopolamine is a nonselective muscarinic antagonist. The mechanism of action of the …
of … Scopolamine is a nonselective muscarinic antagonist. The mechanism of action of the …
[HTML][HTML] Why an M1 antagonist could be a more selective model for memory impairment than scopolamine
… non-selective muscarinic receptor antagonist scopolamine has been used as a drug that
impairs memory performance in man. The notion that scopolamine … At present, scopolamine is …
impairs memory performance in man. The notion that scopolamine … At present, scopolamine is …
The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies
I Klinkenberg, A Blokland - Neuroscience & Biobehavioral Reviews, 2010 - Elsevier
… of nonselective muscarinic drugs other than scopolamine is … be put forward as an alternative
for scopolamine). The specific … several additional nonselective muscarinic antagonists have …
for scopolamine). The specific … several additional nonselective muscarinic antagonists have …
Scopolamine as an antidepressant: a systematic review
RJ Jaffe, V Novakovic, ED Peselow - Clinical neuropharmacology, 2013 - journals.lww.com
… for the anticholinergic medication scopolamine hydrobromide. Scopolamine is a centrally
acting competitive inhibitor of the muscarinic cholinergic receptor site. It is nonselective among …
acting competitive inhibitor of the muscarinic cholinergic receptor site. It is nonselective among …
Scopolamine induced memory impairment; possible involvement of NMDA receptor mechanisms of dorsal hippocampus and/or septum
F Khakpai, M Nasehi, A Haeri-Rohani, A Eidi… - Behavioural brain …, 2012 - Elsevier
… In the present study, the effect of pre-training intra-dorsal hippocampal (CA1) and intra-medial
septal (MS) administration of scopolamine, a nonselective muscarinic acetylcholine …
septal (MS) administration of scopolamine, a nonselective muscarinic acetylcholine …
Inhibitory avoidance memory deficit induced by scopolamine: Interaction of cholinergic and glutamatergic systems in the ventral tegmental area
… In the present study the effect of intra-VTA administration of a nonselective muscarinic …
administration of a nonselective muscarinic acetylcholine receptor antagonist, scopolamine, and a …
administration of a nonselective muscarinic acetylcholine receptor antagonist, scopolamine, and a …
Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates
NMJ Rupniak, SJ Tye, SD Iversen - Journal of the neurological sciences, 1992 - Elsevier
… Peripheral toxicity may explain the disappointing therapeutic effects of nonselective … , caused
partial reversal of the disruptive effects of scopolamine on cognition. However, performance …
partial reversal of the disruptive effects of scopolamine on cognition. However, performance …
[HTML][HTML] GABA interneurons mediate the rapid antidepressant-like effects of scopolamine
ES Wohleb, M Wu, DM Gerhard… - The Journal of …, 2016 - Am Soc Clin Investig
… Clinical reports have revealed that scopolamine, a nonselective … to scopolamine have not
been determined. Here, we demonstrate that the antidepressant-like effects of scopolamine are …
been determined. Here, we demonstrate that the antidepressant-like effects of scopolamine are …
Different effects of scopolamine on the retrieval of spatial memory and fear memory
… non-selective muscarinic antagonist scopolamine … scopolamine 20 min before the testing
in the water maze show impaired spatial memory retrieval. Whereas injection of scopolamine …
in the water maze show impaired spatial memory retrieval. Whereas injection of scopolamine …
M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine
JM Witkin, C Overshiner, X Li, JT Catlow… - … of Pharmacology and …, 2014 - ASPET
… Scopolamine produces rapid and significant symptom … Scopolamine is a nonselective
muscarinic acetylcholine … ) mice had a blunted response to scopolamine in the forced-swim assay. …
muscarinic acetylcholine … ) mice had a blunted response to scopolamine in the forced-swim assay. …