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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …
[PDF][PDF] Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
Honey: Chemical composition, stability and authenticity
The aim of this review is to describe the chemical characteristics of compounds present in
honey, their stability when heated or stored for long periods of time and the parameters of …
honey, their stability when heated or stored for long periods of time and the parameters of …
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
[PDF][PDF] Fibroblast heterogeneity and immunosuppressive environment in human breast cancer
A Costa, Y Kieffer, A Scholer-Dahirel, F Pelon… - Cancer cell, 2018 - cell.com
Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels of …
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels of …
Work team trust and effectiveness
AC Costa - Personnel review, 2003 - emerald.com
This article aims to explore the nature and functioning of trust in work teams. Trust is defined
as a multi‐component variable with distinct but related dimensions. These include …
as a multi‐component variable with distinct but related dimensions. These include …
Critical review on biofilm methods
Biofilms are widespread in nature and constitute an important strategy implemented by
microorganisms to survive in sometimes harsh environmental conditions. They can be beneficial …
microorganisms to survive in sometimes harsh environmental conditions. They can be beneficial …
[PDF][PDF] ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function
T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees… - Neuron, 2015 - cell.com
The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and
FTD remain controversial. We propose a model in which low-complexity (LC) domains of …
FTD remain controversial. We propose a model in which low-complexity (LC) domains of …
Trust within teams: The relation with performance effectiveness
The acknowledgement that trust is important for the functioning of organizations has increased
the demand for research showing how this importance is reflected on the behaviour of its …
the demand for research showing how this importance is reflected on the behaviour of its …
New insights into consumer-led food product development
AIA Costa, WMF Jongen - Trends in food science & technology, 2006 - Elsevier
This paper builds upon a review of relevant marketing, consumer science and innovation
management literature to introduce the concept of consumer-led new product development …
management literature to introduce the concept of consumer-led new product development …