Over 600 million years ago, animals evolved from a unicellular or colonial organism whose
cell (s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar …

The morphological term 'amoeboid'migration subsumes a number of rather distinct
biophysical modes of cellular locomotion that range from blebbing motility to entirely actin …

All metazoan cells carry transmembrane receptors of the integrin family, which couple the
contractile force of the actomyosin cytoskeleton to the extracellular environment. In …

As physical entities, living cells possess structural and physical properties that enable them
to withstand the physiological environment as well as mechanical stimuli occurring within …

The molecular requirements and morphology of migrating cells can vary depending on
matrix geometry; therefore, predicting the optimal migration strategy or the effect of …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Genes linked to human diseases often function in evolutionarily conserved pathways, which
can be readily dissected in simple model organisms. Because of its short lifespan and well …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

We develop a mathematical model that describes key details of actin dynamics in protrusion
associated with cell motility. The model is based on the dendritic-nucleation hypothesis for …

In most organisms, the whole genome is maintained throughout the life span. However,
exceptions occur in some species where the genome is reduced during development …