The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …

Both acetylcholine and glutamate are now thought to play important roles in memory. Recent
evidence suggests that the interaction of these two neurotransmitters may be important for …

We evaluated Ts65Dn Down's syndrome mice and their littermates (LM) at 1–2, 4, and 12
months of age to determine amyloid precursor protein (APP)-related cellular and …

A number of in vitro studies have shown that activation of muscarinic receptors by
cholinergic agonists stimulates the nonamyloidogenic, α-secretase-processing pathway of …

Alzheimer's disease (AD) is a common neurodegenerative disorder and a leading cause of
death among the elderly. Recent advances in our understanding of the neurobiology of AD …

Alzheimer's disease involves progressive degeneration of the cortex and the limbic system.
Loss of afferent forebrain neurochemical modulatory systems is also seen, most significantly …

The limited effect of AChE inhibitors and NMDA receptor antagonists for the treatment of the
cognitive symptoms of Alzheimer's disease has prompted the search for new drugs that are …

Two methods of measuring body temperature were compared in common marmosets.
Subcutaneous temperatures were measured remotely via previously implanted …

Broad evidence from preclinical and clinical research indicates that cholinergic
neurotransmission contributes significantly to the generation of rapid eye movement (REM) …

Hepatotoxicity limits the clinical utility of the cholinesterase inhibitor tacrine as a palliative
therapy for Alzheimer's disease. The present studies examined the effects of E2020, a …