Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Nanoparticles have many potential applications in tumor therapy. Systemically administered
nanoparticles should remain in circulation for a long time to increase their accumulation in …

Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Encapsulation of therapeutic agents in polymer particles has been successfully used in the
development of new drug carriers. A number of design parameters that govern the functional …

The endothelial cell (EC) lining of the pulmonary vasculature forms a semipermeable barrier
between the blood and the interstitium of the lung. Disruption of this barrier occurs during …

Formins are highly conserved proteins that have essential roles in remodelling the actin and
microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work …

Linkage of microtubules to special cortical regions is essential for cell polarization. CLIP-170
binds to the growing ends of microtubules and plays pivotal roles in orientation. We have …

In eukaryotic cells, microtubules and their associated motor proteins can be organized into
various large-scale patterns. Using a simplified experimental system combined with …

Rab7 is a small GTPase that controls transport to endocytic degradative compartments. Here
we report the identification of a novel 45 kDa protein that specifically binds Rab7GTP at its C …

Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …