Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As
such there is a strong interest in developing new means, such as vaccines and microbicides …

Centrioles are essential for the formation of cilia and flagella. They also form the core of the
centrosome, which organizes microtubule arrays important for cell shape, polarity, motility …

Microtubules are born and reborn continuously, even during quiescence. These polymers
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …

Cryo-electron tomography (cryo-ET) is a revolutionary technique for resolving the structure
of subcellular organelles and macromolecular complexes in their cellular context. However …

How microtubules (MTs) are generated in the cell is a major question in understanding how
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …

Synthetic polypeptides derived from the ring-opening polymerization of N-
carboxyanhydrides can spontaneously fold into stable secondary structures under specific …

Summary Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, but the
mechanism underlying its recruitment to mammalian centrioles is not understood. In flies …