Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Antibiotics are recognized widely for their benefits when used appropriately. However, they
are often used inappropriately despite the importance of responsible use within good clinical …

Ethnopharmacological relevance African traditional medicine is one of the oldest and most
diverse practices for treating ailments and numerous natural products have been …

Background Bioactive lipids produced by human cells or by the gut microbiota might play an
important role in health and disease. Dietary intakes are key determinants of the gut …

The widespread usage of antimicrobials has driven the evolution of resistance in pathogenic
microbes, both increased prevalence of antimicrobial resistance genes (ARGs) and their …

The human gut microbiome composition is generally in a stable dynamic equilibrium, but it
can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent …

Background Pathogen infections seriously affect host health, and the use of antibiotics
increases the risk of the emergence of drug-resistant bacteria and also increases …

Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing
features. However, many bacteria carry" cryptic" plasmids that do not confer clear beneficial …

Background A growing body of evidence suggests that the gut microbiota is strongly linked
to general human health. Microbiome-directed interventions, such as diet and exercise, are …

Non-caloric artificial sweeteners have been widely permitted as table sugar substitutes with
high intensities of sweetness. They can pass through the intestinal tract without significant …