Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high
eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus …

Microtubules (MTs) are highly dynamic polymers that constitute the cellular cytoskeleton and
play a role in multiple cellular functions. Variability characterizes biological systems and is …

Hydrogen peroxide (H2O2) is an oxidizing agent that induces cellular damage at
inappropriate concentrations and gives rise to an arrest during cell cycle progression …

Cryo-electron tomography (cryo-ET) is a revolutionary technique for resolving the structure
of subcellular organelles and macromolecular complexes in their cellular context. However …

Radial glial progenitor cells (RGPs) are the major neural progenitor cells that generate
neurons and glia in the developing mammalian cerebral cortex,,–. In RGPs, the centrosome …

Microtubules play important roles in biological functions by forming superstructures, such as
doublets and branched structures, in vivo. Despite the importance, it is challenging to …

Highlights•Enucleation is a rate-limiting step in erythropoiesis that leads to the formation of
RBCs.•Regulators of enucleation range from transcription factors to miRNAs.•Optimum …

As one of four filament types, microtubules are a core component of the cytoskeleton and are
essential for cell function. Yet how microtubules are nucleated from their building blocks, the …

Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature
osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the …

Precise spatiotemporal control of microtubule nucleation and organization is critical for
faithful segregation of cytoplasmic and genetic material during cell division and signaling via …