Authors
Jack Bleesing, Anne Prada, David M Siegel, Joyce Villanueva, Judyann Olson, Norman T Ilowite, Hermine I Brunner, Thomas Griffin, Thomas B Graham, David D Sherry, Murray H Passo, Athimalaipet V Ramanan, Alexandra Filipovich, Alexei A Grom
Publication date
2007/3
Journal
Arthritis & Rheumatism
Volume
56
Issue
3
Pages
965-971
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Objective
Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion of T cells and hemophagocytic macrophages. Levels of soluble interleukin‐2 receptor α (sIL‐2Rα) and soluble CD163 (sCD163) may reflect the degree of activation and expansion of T cells and macrophages, respectively. This study was undertaken to assess the value of serum sIL‐2Rα and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA).
Methods
Enzyme‐linked immunosorbent assay was used to assess sIL‐2Rα and sCD163 levels in sera from 7 patients with acute macrophage activation syndrome complicating systemic JIA and 16 patients with untreated new‐onset systemic JIA. The results were correlated with clinical features of established macrophage activation syndrome, including ferritin levels …
Total citations
Scholar articles
J Bleesing, A Prada, DM Siegel, J Villanueva, J Olson… - Arthritis & Rheumatism, 2007