Methods| This study was approved by the ethics committee at University College London, and written informed consent was obtained from the participants. A 3-T fMRI scan was performed on 2 pain-free individuals (1 woman) and 4 agematched control individuals. Participants received 24 mechanical stimuli (465 mN, 0.2-mm tip, 1-second duration) to their right hand dorsum. Functional MRI results from thermal stimuli are not reported owing to motion artifacts. Participants rated the intensity of both subjective sensation (0= no sensation and 10= most intense sensation imaginable) and pain (0= no pain and 10= most intense pain imaginable). General linear model analysis of fMRI data was performed using the Functional Imaging Statistics Library, 6 using a cluster correction for multiple comparisons (z= 1.96, P<. 05) at single-participant level and a conjunction analysis at the group level such that group activations …