Authors
Kim Doré, Sébastien Dubus, Hoang-Anh Ho, Isabelle Lévesque, Maryse Brunette, Geneviève Corbeil, Maurice Boissinot, Guy Boivin, Michel G Bergeron, Denis Boudreau, Mario Leclerc
Publication date
2004/4/7
Journal
Journal of the American Chemical Society
Volume
126
Issue
13
Pages
4240-4244
Publisher
American Chemical Society
Description
We report the specific detection of a few hundred molecules of genetic material using a fluorescent polythiophene biosensor. Such recognition is based on simple electrostatic interactions between a cationic polymeric optical transducer and the negatively charged nucleic acid target and can be done in less than 1 h, simply and affordably, and without any chemical reaction. This simple system is versatile enough to detect nucleic acids of various lengths, including a segment from the RNA genome of the Influenza virus.
Total citations
Scholar articles
K Doré, S Dubus, HA Ho, I Lévesque, M Brunette… - Journal of the American Chemical Society, 2004