Valenzuela is a surname that originated in Spain. Notable people with the name include:
- Alfred Valenzuela, Mexican-American United States Army general
- Arturo Valenzuela, Chilean-American academic
- Cristina Valenzuela, American voice actress
- Eric Valenzuela, American college baseball coach
- Fernando de Valenzuela, 1st Marquis of Villasierra, Spanish royal favourite and minister
- Fernando Valenzuela, Mexican former professional baseball pitcher
- Ismael Valenzuela, American horse racing jockey
- Jesse Valenzuela, American musician
- Juan Carlos Valenzuela (footballer), Mexican footballer
- Juan Carlos Valenzuela (politician), Honduran politician
- Laura Valenzuela, birth name Rocío Espinosa López-Cepero, Spanish television host, actress, and model
- Luis Malla Valenzuela, Chilean politician
- Luisa Valenzuela, post-modern Argentine novelist
- Pat Valenzuela, American horse racing jockey, nephew of Ismael Valenzuela
- Pío Valenzuela, Filipino physician and patriot
- Ricardo Valenzuela, American former soccer referee
- Richard Valenzuela, birth name of Mexican-American musician Ritchie Valens