| RASA2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RASA2, GAP1M, RAS p21 protein activator 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601589 MGI: 2149960 HomoloGene: 4745 GeneCards: RASA2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. [5]
Function[edit]
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000155903 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032413 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.
Further reading[edit]
- Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ (March 1999). "Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo". Curr. Biol. 9 (5): 265–8. doi:10.1016/s0960-9822(99)80116-x. PMID 10074452. S2CID 8695013.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.