Pedro Ponce de León was a Benedictine monk.

Pedro Ponce de León may also refer to:

• Pedro Ponce de León (bishop of Plasencia) (1510–1573), Spanish Roman Catholic bishop
• Pedro Ponce de Léon (bishop of Zamora) (born 1561), Spanish Roman Catholic bishop
• Pedro Ponce de León the Elder (died 1352), Castilian nobleman
• Pedro Ponce de León (Adelantado) (died 1314), Castilian nobleman