O’Bannon is an Irish surname. Notable people with the name include:

• Charles O’Bannon (born 1975), American basketball player
• Chuck O'Bannon Jr. (born 1999), American basketball player
• Dan O’Bannon (1946-2009), American screenwriter and film director
• Ed O’Bannon (born 1972), American basketball player and 1995 NCAA Tournament MOP
• Frank O’Bannon (1930–2003), American politician, Governor of Indiana 1997–2003
• Helen O’Bannon (1939–1988), American academic and economist
• Presley O’Bannon (1776–1850), U.S. Marine Corps officer, famous for his exploits in the First Barbary War
• Rockne S. O’Bannon (born 1955), American television writer and producer

• Bannon, surname