The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily docosahexaenoic acid) without the direct action of cyclooxygenase (COX) enzymes. The result is the formation of isoprostane-like compounds F4-, D4-, E4-, A4-, and J4-neuroprostanes which have been shown to be produced in vivo.[1] These oxygenated essential fatty acids possess potent biological activity as anti-inflammatory mediators inhibiting the response of human macrophages that augment the perception of pain.[2]
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References[edit]
- ^ Jacson, Roberts (2005). "The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation". Brain Pathology. 15 (2): 143–148. doi:10.1111/j.1750-3639.2005.tb00511.x. PMC 8095955. PMID 15912887. S2CID 43236072.
- ^ Gladine, Laurie (2014). "Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages" (PDF). Free Radic. Biol. 75 (S1): S15. doi:10.1016/j.freeradbiomed.2014.10.590. PMID 26461294.