The following highways are numbered 599:

Canada[edit]

• Alberta Highway 599
• Ontario Highway 599

Ireland[edit]

• R599

United Kingdom[edit]

• A599

United States[edit]

• Florida State Road 599 – hidden designation for a portion of U.S. Route 41 in and near Tampa
• Kentucky Route 599
• Nevada State Route 599
• New Mexico State Road 599
• Puerto Rico Highway 599
• Texas Farm to Market Road 599
• Washington State Route 599