THC Science

Lenampicillin
Clinical data
Trade names	Takacillin, Varacillin
Other names	KBT-1585
Legal status
Legal status	Rx in Japan;
Identifiers
	IUPAC name (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;
CAS Number	86273-18-9;
PubChem CID	65646;
UNII	8M568DM08K;
CompTox Dashboard (EPA)	DTXSID1057901 ;
Chemical and physical data
Formula	C21H23N3O7S
Molar mass	461.49 g·mol−1

Lenampicillin is an antibiotic drug of the penicillin class. It is a produg of ampicillin; after oral administration of lenampicillin, ampicillin is rapidly formed.^[1]

Lenampicillin inhibits bacterial penicillin binding proteins (transpeptidase) and is effective against a wide range of bacterial infections.^[2]

Lenampicillin was developed in Japan and has been marketed there.^[2]

References[edit]

^ Saito A, Nakashima M (May 1986). "Pharmacokinetic study of lenampicillin (KBT-1585) in healthy volunteers". Antimicrobial Agents and Chemotherapy. 29 (5): 948–950. doi:10.1128/aac.29.5.948. PMC 284190. PMID 3729355.
^ ^a ^b "Lenampicillin". InxightDrugs. National Center for Advancing Translational Sciences.