Khotkovo (Russian: Хотьково) is the name of several inhabited localities in Russia.

Urban localities

• Khotkovo, Moscow Oblast, a town in Sergiyevo-Posadsky District of Moscow Oblast

Rural localities

• Khotkovo, Kaluga Oblast, a selo in Duminichsky District of Kaluga Oblast
• Khotkovo, Oryol Oblast, a selo in Khotkovsky Selsoviet of Shablykinsky District in Oryol Oblast
• Khotkovo, Smolensk Oblast, a village in Duginskoye Rural Settlement of Sychyovsky District in Smolensk Oblast