Huffman is a Bohemian American surname likely derived from the German surname "Hoffman".

Notable people with the surname include:

• Alaina Huffman (born 1980), Canadian actress
• Berl Huffman (1907–1990), American college sports coach
• Booker Huffman (born 1965), American professional wrestler better known as Booker T
• Cady Huffman (born 1965), American actress
• Dave Huffman, former NFL player
• David Huffman, American actor
• David Huffman (artist), contemporary American artist
• David A. Huffman, creator of Huffman coding
• Donald Huffman, American physicist
• Felicity Huffman (born 1962), American actress
• George Huffman (1862–1897), American businessman
• James W. Huffman, United States Senator from Ohio (1945–1946)
• Jared Huffman, United States Representative from California (2013–present)
• Jason Huffman, American politician
• Jim Huffman, law professor and candidate for United States Senate from Oregon
• John W. Huffman, professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids
• Kathy Rae Huffman, art curator for video art, new media art, online and interactive art, based in California, USA.
• Kurt Huffman, American politician
• Lash Huffman (born 1960), American professional wrestler better known as Stevie Ray; brother of Booker T
• Laton Alton Huffman (1854–1931) was an American photographer of Frontier and Native American life
• Maven Huffman (born 1976), American professional wrestler often known by his first name only
• Nate Huffman (1975–2015), American basketball player, 2001 Israeli Basketball Premier League MVP
• Robert Huffman (born 1968), former American stock car racing driver
• Robert E. Huffman, American scientist and author
• Rosanna Huffman, American actress
• Scott Huffman (born 1964), American pole-vaulting champion
• Shirley Huffman (1928–2018), American politician
• Steve Huffman, CEO of Reddit