Holtz is the surname of:
- Alexander Holtz (born 2002), Swedish ice hockey player
- Andrew Holtz, American journalist
- Carl Holtz (1920–2006), American oarsman and farmer
- Daniel Holtz, a fictional character on the TV series Angel
- Eric Holtz (born 1965), American Head Coach of the Israel National Baseball Team
- Jürgen Holtz (1932–2020), German actor on stage and in film, artist and author
- Hyman Holtz (1896–c. 1939), American mobster
- Itshak Holtz (1925–2018), Painter
- Kaila Holtz (born 1981), a 2004 Canadian Olympic softball pitcher
- Lou Holtz (1893–1980), American comedian
- Lou L. Holtz (born 1937), a retired national championship winning college football coach
- Mark Holtz (1945–1997), former broadcaster for the Texas Rangers
- Mike Holtz (born 1972), American baseball player
- Pat Holtz, Scottish pool player
- Sabine Holtz (born 1959), German historian
- Skip Holtz (born 1964), head football coach of University of South Florida
- Stefan Holtz (born 1981), German canoer
- Tenen Holtz (1877–1971), Russian actor
- Thomas R. Holtz, Jr., palaeontologist and senior lecturer in geology at University of Maryland, USA
- Vera Holtz (born 1953), Brazilian actress
- Viktor Holtz (1846–1919), a German educator and a pioneer of German-Japanese academic and cultural relations.
- Wilhelm Holtz (1836–1913), German physicist and inventor of the Holtz machine
- Frederick Holtz, Tigard High School IB Psychology teacher