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Summary
| Description |
English: The human gamma-secretase protein complex solved by cryo-electron microscopy, containing nicastrin (red), presenilin-1 (orange), PEN-2 (blue), and APH-1 (green). The complex is located in the membrane of the endoplasmic reticulum, whose lumenal side is shown in red and cytoplasmic side in blue. Gamma-secretase is the protease responsible for processing amyloid precursor protein (APP) to Aβ peptide.
Image rendered using PyMol from PDB ID 5A63: Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H. W. Scheres, Yigong Shi. (2015). An atomic structure of human γ-secretase. Nature 525, 212–217 (10 September 2015) doi:10.1038/nature14892. |
| Date | |
| Source | Own work |
| Author | Opabinia regalis |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 01:19, 25 November 2015 | | 958 × 1,116 (742 KB) | Opabinia regalis | {{Information |Description ={{en|1=The human gamma-secretase protein complex solved by cryo-electron microscopy, containing nicastrin (red), presenilin-1 (orange), presenilin-2 (blue), and APH-1 (green). The complex is located in the membrane of the... |
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