Edward Stafford may refer to:

• Edward Stafford, 2nd Earl of Wiltshire (1470–1498)
• Edward Stafford, 3rd Duke of Buckingham (1478–1521), executed for treason
• Edward Stafford, 3rd Baron Stafford (1535–1603)
• Sir Edward Stafford (diplomat) (1552–1605), English ambassador to Paris and MP
• Edward Stafford, 4th Baron Stafford (1572–1625)
• Sir Edward Stafford (politician) (1819–1901), Premier of New Zealand
• Ed Stafford (born 1975), British explorer
• Edward Stephen Stafford, editor of The Johns Hopkins Medical Journal

• Edward Stafford (The Tudors), a fictionalized version of the 3rd Duke of Buckingham, on the TV show "The Tudors"

• All pages with titles containing Edward Stafford
• Stafford (surname)
• Stafford (disambiguation)