Protein-coding gene in the species Homo sapiens
EPHA3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GSF , 2QO7 , 2QO9 , 2QOB , 2QOC , 2QOD , 2QOF , 2QOI , 2QOK , 2QOL , 2QON , 2QOO , 2QOQ , 3DZQ , 3FXX , 3FY2 , 4G2F , 4GK2 , 4GK3 , 4GK4 , 4L0P , 4P4C , 4P5Q , 4P5Z , 4TWN , 4TWO
Identifiers Aliases EPHA3 , Epha3, AW492086, Cek4, ETK1, End3, Hek, Hek4, Mek4, Tyro4, EK4, ETK, EPH receptor A3, HEK, HEK4, TYRO4External IDs OMIM : 179611 MGI : 99612 HomoloGene : 21083 GeneCards : EPHA3 Wikidata
EPH receptor A3 (ephrin type-A receptor 3 ) is a protein that in humans is encoded by the EPHA3 gene .[5] [6] [7]
Function [ edit ]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[7]
Interactions [ edit ]
EPH receptor A3 has been shown to interact with EFNB2 [8] [9] and EFNA5 .[9] [10]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000044524 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052504 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (March 1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line" . J Biol Chem . 267 (5): 3262–7. doi :10.1016/S0021-9258(19)50725-6 . PMID 1737782 .
^ Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines" . Proc Natl Acad Sci U S A . 89 (5): 1611–5. Bibcode :1992PNAS...89.1611W . doi :10.1073/pnas.89.5.1611 . PMC 48502 . PMID 1311845 .
^ a b "Entrez Gene: EPHA3 EPH receptor A3" .
^ Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases" . Mol. Immunol . 32 (16): 1197–205. doi :10.1016/0161-5890(95)00108-5 . PMID 8559144 .
^ a b Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW (June 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor" . J. Biol. Chem . 272 (26): 16521–30. doi :10.1074/jbc.272.26.16521 . PMID 9195962 .
^ Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine . 9 (8): 540–9. doi :10.1006/cyto.1997.0199 . PMID 9245480 .
Further reading [ edit ]
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci . 21 : 309–45. doi :10.1146/annurev.neuro.21.1.309 . PMID 9530499 .
Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther . 77 (3): 151–81. doi :10.1016/S0163-7258(97)00112-5 . PMID 9576626 .
Ernst AF, Jurney WM, McLoon SC (1999). "Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide". Prog. Brain Res . 118 : 115–31. doi :10.1016/S0079-6123(08)63204-5 . PMID 9932438 .
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development . 126 (10): 2033–44. doi :10.1242/dev.126.10.2033 . PMID 10207129 .
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol . International Review of Cytology. 196 : 177–244. doi :10.1016/S0074-7696(00)96005-4 . ISBN 9780123646002 . PMID 10730216 .
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning" . Philos. Trans. R. Soc. Lond. B Biol. Sci . 355 (1399): 993–1002. doi :10.1098/rstb.2000.0635 . PMC 1692797 . PMID 11128993 .
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci . 2 (3): 155–64. doi :10.1038/35058515 . PMID 11256076 . S2CID 205014301 .
Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors" . EMBO J . 13 (16): 3757–62. doi :10.1002/j.1460-2075.1994.tb06685.x . PMC 395287 . PMID 8070404 .
Wicks IP, Lapsys NM, Baker E, Campbell LJ, Boyd AW, Sutherland GR (1994). "Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2". Genomics . 19 (1): 38–41. doi :10.1006/geno.1994.1009 . PMID 8188238 .
Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases" . Mol. Immunol . 32 (16): 1197–205. doi :10.1016/0161-5890(95)00108-5 . PMID 8559144 .
Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW (1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor" . J. Biol. Chem . 272 (26): 16521–30. doi :10.1074/jbc.272.26.16521 . PMID 9195962 .
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine . 9 (8): 540–9. doi :10.1006/cyto.1997.0199 . PMID 9245480 .
Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee" . Cell . 90 (3): 403–4. doi :10.1016/S0092-8674(00)80500-0 . PMID 9267020 . S2CID 26773768 .
Lackmann M, Oates AC, Dottori M, Smith FM, Do C, Power M, Kravets L, Boyd AW (1998). "Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization" . J. Biol. Chem . 273 (32): 20228–37. doi :10.1074/jbc.273.32.20228 . PMID 9685371 .
Ciossek T, Monschau B, Kremoser C, Löschinger J, Lang S, Müller BK, Bonhoeffer F, Drescher U (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci . 10 (5): 1574–80. doi :10.1046/j.1460-9568.1998.00180.x . PMID 9751130 . S2CID 20470923 .
Activity Regulation Classification Kinetics Types
Angiopoietin CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: Ersofermin
FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A
TrkB
Agonists: 3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors: Adrenomedullin
Colony-stimulating factors (see here instead)
Connective tissue growth factor (CTGF)
Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )
Erythropoietin (see here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /T-cell growth factors (see here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see here instead)
Wnt signaling proteins
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)