Death's Head, death's head or death's-head may refer to:
- Skull and crossbones (symbol)
- Death's head cockroach (Blaberus craniifer), a species of cockroach
- Death's-head hawkmoth, the common name for three species of moth
- Death's Head, a Marvel character and enemy of Daredevil
- Death's Head (series), science fiction novels by David Gunn
- The official "death's head" insignia design of the Hells Angels Motorcycle Club.
- Totenkopf (German; erroneously translated as "death's head"), a military insignia
- The Blood Beast Terror, also known as The Deathshead Vampire, a 1968 British horror film starring Peter Cushing