David Kessler may refer to:

• David Kessler (actor) (1860–1920), Yiddish theater
• David A. Kessler (born 1951), FDA Commissioner, university medical dean
• David R. Kessler (born 1957), Pennsylvania state representative, elected 2006
• David Kessler (author) (born 1957), English thriller writer
• David Kessler (writer) (born 1959), death and grieving expert
• David F. Kessler (1906–1999), managing director of The Jewish Chronicle
• David T. Kessler (born 1950), American artist
• David Kessler, character in An American Werewolf in London