Protein-coding gene in the species Homo sapiens
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene .[5] [6] [7]
Interactions [ edit ] CTDSP1 has been shown to interact with SNAI1 .[8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility" . Journal of Human Genetics . 47 (3): 140–5. doi :10.1007/s100380200016 PMID 11950066 . ^ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5" . The Journal of Biological Chemistry . 278 (28): 26078–85. doi :10.1074/jbc.M301791200 PMID 12721286 . ^ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1" .^ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation" . The Journal of Biological Chemistry . 284 (1): 640–8. doi :10.1074/jbc.M806916200 PMC 2610500 PMID 19004823 .
Further reading [ edit ]
Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome . 11 (9): 755–62. doi :10.1007/s003350010151 . PMID 10967134 . S2CID 11308779 . Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW, Schonmann V, et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". Journal of Neuroscience Research . 75 (4): 461–71. doi :10.1002/jnr.10882 . PMID 14743429 . S2CID 29467544 . Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN (January 2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science . 307 (5709): 596–600. Bibcode :2005Sci...307..596Y . doi :10.1126/science.1100801 . PMID 15681389 . S2CID 39722809 . Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways" . The Journal of Biological Chemistry . 281 (52): 40412–9. doi :10.1074/jbc.M610172200 PMID 17085434 .
External links [ edit ]
PDB gallery
1t9z : Three-dimensional structure of a RNA-polymerase II binding protein.
1ta0 : Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.
2ghq : CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
2ght : CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
